25I-NBOH: Difference between revisions

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* Warning: This chemical is active in the microgram (µg) range! Please use extreme caution if working with this substance, a milligram scale and liquid measurement are VITAL! Please start with doses of 500µg or less!
* Warning: This chemical is active in the microgram (µg) range! Please use extreme caution if working with this substance, a milligram scale and liquid measurement are VITAL! Please start with doses of 500µg or less!
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25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [[2C-I]]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, similar to the better-known compound 25I-NBOMe, '''making it some twelve times the potency of 2C-I itself'''.  
25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [[2C-I]]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, similar to the better-known compound 25I-NBOMe, making it some twelve times the potency of 2C-I itself. In vitro tests showed this compound acted as an agonist but animal studies have not been reported. While the N-benzyl derivatives of 2C-I were significantly increased in binding activity to 5HT2A receptor fragments, compared to 2C-I, the N-benzyl derivatives of DOI were less active, compared to DOI.


It was discovered in 2006 by a team at Purdue University.
It was discovered in 2006 by a team at Purdue University.

Revision as of 12:26, 19 April 2014

Safety profile
Category:
  • Psychedelic
Main effects:
  • Open and closed eye visuals, euphoria, change in perception of time
Side effects:
  • Nausea, vasoconstriction (mostly when combined with other vasoconstricting substances like LSD), unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
Health risks:
  • paranoia, fear, and panic, dystonia (rare), seizure (rare), death (rare)
Important safety remarks:
  • 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
  • Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN!
  • Warning: This chemical is active in the microgram (µg) range! Please use extreme caution if working with this substance, a milligram scale and liquid measurement are VITAL! Please start with doses of 500µg or less!


25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, similar to the better-known compound 25I-NBOMe, making it some twelve times the potency of 2C-I itself.

It was discovered in 2006 by a team at Purdue University.

Links

Reference

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