Mescaline: Difference between revisions

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== Chemical and physical properties ==
== Chemical and physical properties ==


For solubility, melting point, etc, check the [[Psychedelic Compounds Chemical and Physical Properties#Mescaline|Mescaline Chemical and Physical Properties]] WIKI


3,4,5-trimethoxyphenethylamine
== Effects ==
 
Extremely long, slow comeup, lasting 2+ hours.  Nausea or purging for some, not for others.  Higher doses can increase chances of purging, feeling of being poisoned and dizziness/difficulty standing/walking.  Lower to mid doses could yield a feeling of nausea quickly followed by a "rolling" sense of euphoria.


=== Freebase Mescaline ===
Trip is extremely long lasting - 10-14 hours plus.
<table><tr><td>[[Image:mescalinefreebase.png]]</td><td></table>
* CAS Registry Number:  54-04-6
* Composition: C11H17NO3
* Melting point: 35-36°C (Kindler and Peschke, 103.  [http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 180°C (12 mmHg)
* XLogP: 0.6 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* XLogP3: 0.7 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4076&loc=ec_rcs PubChem])
* pKa: 9.56
* Appearance: long needle shaped white crystals
* Molecular weight: 211.26
Notes: forms mescaline carbonate on prolonged exposure to air
* Average dose: 300 to 600 milligrams with a duration of 5 to 12 hours.
* Colorimetric reagent results: [https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=25771 Here]
* Solubility
Soluble in: alcohol, chloroform, benzene, xylene, toluene, acetone, dichloromethane, highly soluble in isopropyl alcohol, soluble in d-limonene


Moderately soluble in: water
Color and music enhancement are exquisite.


Insoluble in: practically insoluble in ether or petroleum ether
Visuals are more organic looking than LSD.  More rounded corners, fewer sharp edges, in every sense of the term. Colors are deeply and thoroughly saturated.
* LD50: i.p. rats 370 mg/kg


=== Mescaline Citrate ===
== Pharmacology, toxicity and general safety ==
* Solubility
Soluble in water


Insoluble in: xylene, acetone <nowiki>*</nowiki>
== Plants containing mescaline ==


<nowiki>*</nowiki> Possible unreliable web source.
== Extraction teks ==


=== Mescaline Hydrochloride ===
== Dosages and consumption methods ==
<table><tr><td>[[Image:mescalinehcl.png]]</td><td></table>
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity.
* Molecular weight: 247.72 (Sigma Aldrich)
* Empirical Formula (Hill Notation): C11H17NO3 • HCl (Sigma Aldrich)
* CAS Number: 832-92-8
* Appearance: colorless crystals, needles
* Melting point: 184°C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Moderately soluble in: water, alcohol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index]), methanol (at least 1.0 mg/ml, source Sigma Aldrich solution)
(Merck Index)
Insoluble in: practically insoluble in toluene and acetone, insoluble in isopropyl alcohol, diethyl ether, and d-limonene
* LD50: i.p. rats 132 mg/kg
* Storage temperature: 2-8°C (Sigma Aldrich)
* Isolation: when mescaline hydrochloride is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in IPA or acetone (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the IPA or acetate, while the mescaline hydrochloride does not. Note that for the cleanest results use about 2 washes of acetone, and then 2 washes with IPA.


=== Mescaline Picrate ===
* Melting point: mp 222°C.


=== Mescaline Sulfate Dihydrate ===
Oral Dosage<ref>Mescaline Oral Dosage[https://m.psychonautwiki.org/wiki/Mescaline]</ref>:
<table><tr><td>[[Image:mescalinesulfate.png]]</td><td></table>
*Threshold 50 mg
* Composition: (C11H17NO3)2 • H2SO4 • 2H2O
*Light 100 - 200 mg
* Appearance: prisms
*Common 200 - 400 mg
* Melting point: 183–186 °C (361–367 °F)
*Strong 400 - 800 mg
* Molecular Weight: 309.33606
*Heavy 800 mg+
* Soluble in: hot water, methanol
* Almost insoluble in: near freezing water, alcohol, acetone <nowiki>*</nowiki>
<nowiki>*</nowiki> Possible unreliable web source.


=== Mescaline Fumarate ===
* Composition: unknown (it may be a one to one salt or may not be)
* Appearance: White powder
* Melting point: unknown
* Solubility
Soluble in: water


Insoluble in: Limonene, Anydrous IPA, Acetone, MEK (most likely insoluble in all non-polars like xylene and toluene) [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=18705 Source]
Duration 8 - 12 hours:
*Onset 45 - 90 minutes
*Come up 60 - 120 minutes
*Peak 4 - 6 hours
*Comedown 2 - 3 hours


=== Mescaline Acetate ===
* Composition: unknown
* Appearance: white free flowing powder with a slight waxy texture <nowiki>***</nowiki>
* Melting point: unknown
* Solubility:
Soluble in: water<nowiki>***</nowiki>, isopropyl alcohol<nowiki>***</nowiki>, acetone<nowiki>***</nowiki>, DMSO<nowiki>***</nowiki> (more than 5 grams/100 ml), boiling MEK***


Insoluble in: xylene, d-limonene, cold MEK (Methyl Ethyl Ketone) <nowiki>***</nowiki>
After effects 6 - 36 hours


<nowiki>***</nowiki> This information was validated by SWIM and is reliable.
* Isolation: when mescaline acetate is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in cold MEK (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the MEK, while the mescaline acetate does not. Mescaline acetate can be recrystallized in MEK by boiling the MEK and then freezing it overnight.


== Effects ==
Mescaline is usually in a solid salt form. The type of salt can slightly affect dosage. In general the HCl salt is 90% stronger than other forms usually encountered.


== Pharmacology, toxicity and general safety ==


== Plants containing mescaline ==
Product needed to carry one millimol of mescaline:
*Mescaline FB (reference, not encountered): 212mg
*Mescaline HCl: 248mg
*Mescaline Acetate: 271mg
*Mescaline Citrate: 275mg
*Mescaline Hydrogen Citrate: 307mg
*Mescaline Dihydrogen Citrate: 402mg
*Mescaline Malate: 278mg
*Mescaline Sulfate Dihydrate: 278mg
*Mescaline Bicarbonate (rare): 274mg†


== Extraction teks ==


== Dosages and consumption methods ==
''†Bicarbonate form is assumed since carbonic acid's Pka2 > Mescaline's Pka''


== History of usage ==
== History of usage ==


== Analysis of Mescaline ==
== Analysis of Mescaline ==
NMR 1H
[[File:H1mesc.jpg]]
GC-MS (EI)
[[File:MescGCMS.jpg]]


== Scientific publications ==
== Scientific publications ==

Latest revision as of 10:32, 6 July 2021

Brief overview - What is Mescaline?

Chemical and physical properties

For solubility, melting point, etc, check the Mescaline Chemical and Physical Properties WIKI

Effects

Extremely long, slow comeup, lasting 2+ hours. Nausea or purging for some, not for others. Higher doses can increase chances of purging, feeling of being poisoned and dizziness/difficulty standing/walking. Lower to mid doses could yield a feeling of nausea quickly followed by a "rolling" sense of euphoria.

Trip is extremely long lasting - 10-14 hours plus.

Color and music enhancement are exquisite.

Visuals are more organic looking than LSD. More rounded corners, fewer sharp edges, in every sense of the term. Colors are deeply and thoroughly saturated.

Pharmacology, toxicity and general safety

Plants containing mescaline

Extraction teks

Dosages and consumption methods

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity.


Oral Dosage[1]:

  • Threshold 50 mg
  • Light 100 - 200 mg
  • Common 200 - 400 mg
  • Strong 400 - 800 mg
  • Heavy 800 mg+


Duration 8 - 12 hours:

  • Onset 45 - 90 minutes
  • Come up 60 - 120 minutes
  • Peak 4 - 6 hours
  • Comedown 2 - 3 hours


After effects 6 - 36 hours


Mescaline is usually in a solid salt form. The type of salt can slightly affect dosage. In general the HCl salt is 90% stronger than other forms usually encountered.


Product needed to carry one millimol of mescaline:

  • Mescaline FB (reference, not encountered): 212mg
  • Mescaline HCl: 248mg
  • Mescaline Acetate: 271mg
  • Mescaline Citrate: 275mg
  • Mescaline Hydrogen Citrate: 307mg
  • Mescaline Dihydrogen Citrate: 402mg
  • Mescaline Malate: 278mg
  • Mescaline Sulfate Dihydrate: 278mg
  • Mescaline Bicarbonate (rare): 274mg†


†Bicarbonate form is assumed since carbonic acid's Pka2 > Mescaline's Pka

History of usage

Analysis of Mescaline

NMR 1H


GC-MS (EI)

Scientific publications

Other links of interest

  1. ↑ Mescaline Oral Dosage[1]
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