Tetrahydroharmine - Revision history

Trip: /* Pharmacology, toxicity and general safety */

2023-02-12T08:18:14Z

Pharmacology, toxicity and general safety

← Older revision		Revision as of 08:18, 12 February 2023
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	Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.		Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.

	Note: There is still not enough data available to confirm pharmacology pathways, interactions and toxicity.		Note: There is still not enough data available to confirm pharmacology pathways, interactions and toxicity levels.

	== Plants containing THH ==		== Plants containing THH ==

2023-02-12T08:18:02Z

Pharmacology, toxicity and general safety

← Older revision		Revision as of 08:18, 12 February 2023
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	Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.		Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.

	Note: ~~Not~~ enough data available to confirm pharmacology pathways, interactions and toxicity.		Note: There is still not enough data available to confirm pharmacology pathways, interactions and toxicity.

	== Plants containing THH ==		== Plants containing THH ==

2023-02-12T08:17:45Z

Pharmacology, toxicity and general safety

← Older revision		Revision as of 08:17, 12 February 2023
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	Thought to be metabolized similarly to other harmala alkaloids.		Thought to be metabolized similarly to other harmala alkaloids.
	Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.		Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.
	Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with ~~almost any antidepressant~~, stimulants, common migraine ~~medication~~, certain herbs, ~~most~~ cold ~~medicine~~, opiates, nicotine and caffeine.		Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.

	Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.		Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

2023-02-12T08:17:13Z

Pharmacology, toxicity and general safety

← Older revision		Revision as of 08:17, 12 February 2023
Line 31:		Line 31:
	Thought to be metabolized similarly to other harmala alkaloids.		Thought to be metabolized similarly to other harmala alkaloids.
	Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.		Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.
	Like other harmala alkaloids, THH is thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.		Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.

	Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.		Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

2023-02-12T08:16:55Z

Pharmacology, toxicity and general safety

← Older revision		Revision as of 08:16, 12 February 2023
Line 31:		Line 31:
	Thought to be metabolized similarly to other harmala alkaloids.		Thought to be metabolized similarly to other harmala alkaloids.
	Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.		Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.
	Like other harmala alkaloids thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.		Like other harmala alkaloids, THH is thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.

	Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.		Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

2023-02-12T08:13:55Z

History of usage

← Older revision		Revision as of 08:13, 12 February 2023
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	== History of usage ==		== History of usage ==
			As it is found in B. Caapi, it has quite a historic and symbolistic use in traditional ayahuasca brews.

	== Analysis of THH ==		== Analysis of THH ==

2023-02-12T08:12:39Z

Dosages and consumption methods

← Older revision		Revision as of 08:12, 12 February 2023
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	== Dosages and consumption methods ==		== Dosages and consumption methods ==
			Usually used in combination with harmine or other RIMA harmala alkaloids to create a synergistic effect. A usual adjunct to ayahuasca/ pharmahuasca. Can be used in other psychedelics combinations THH/ LSD, THH/ Psilocybin mushrooms etc.

			Dose ranges 50-300mg.

	== History of usage ==		== History of usage ==

2023-02-12T08:09:44Z

Effects

← Older revision		Revision as of 08:09, 12 February 2023
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	== Effects ==		== Effects ==
			Similar effects to other Harmala alkaloids

	== Pharmacology, toxicity and general safety ==		== Pharmacology, toxicity and general safety ==

2023-02-12T08:09:11Z

Plants containing THH

2023-02-12T08:08:56Z

Future Research

← Older revision		Revision as of 08:08, 12 February 2023
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	Potential reduction pathways		Potential reduction pathways

	[[File:4685 2b0909e8-9501-4209-b338-55bbad14ba59 harmaline oxidoreduction.jpg]]		[[File:4685 2b0909e8-9501-4209-b338-55bbad14ba59 harmaline oxidoreduction.jpg]]