1P-LSD - Revision history

GameComplete at 07:42, 24 February 2015

2015-02-24T07:42:12Z

← Older revision		Revision as of 07:42, 24 February 2015
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	[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]		[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]
	* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide		* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
			* Synonym: 1-Propionyl-lysergic acid diethylamide
	----		----

GameComplete at 07:38, 24 February 2015

2015-02-24T07:38:21Z

← Older revision		Revision as of 07:38, 24 February 2015
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	* Psychedelic		* Psychedelic
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	* ~~Open~~ and closed eye visuals, euphoria, change in perception of time~~. Anecdotal report of being indistinguishable from LSD~~.		* Anecdotal report of being indistinguishable from LSD.<ref>[http://www.bluelight.org/vb/threads/745848-The-Big-amp-Dandy-1P-LSD-%281-propionyl-lysergic-acid-diethylamide%29-Thread bluelight.org: The Big & Dandy 1P-LSD (1-propionyl-lysergic acid diethylamide) Thread]</ref>
			* Possible main effects: open and closed eye visuals, euphoria, change in perception of time.
	\|		\|
	* Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing		* Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing

GameComplete at 07:33, 24 February 2015

2015-02-24T07:33:07Z

← Older revision		Revision as of 07:33, 24 February 2015
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	* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.		* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.
	* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}		* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}
			== Chemical and physical properties ==
	[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]		[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]
			* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

	~~== Brief overview~~ - ~~What is 1P~~-~~LSD? ==~~		----
	* Systematic (IUPAC) name: (6aR,9R)-4-~~propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide~~

	~~== Chemical and physical properties ==~~
	From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />		From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />

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	''"I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>''		''"I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>''
	<!--== Effects ==		<!--== Brief overview - What is 1P-LSD? ==

			== Effects ==

	== Pharmacology, toxicity and general safety ==		== Pharmacology, toxicity and general safety ==

GameComplete at 07:30, 24 February 2015

2015-02-24T07:30:32Z

← Older revision		Revision as of 07:30, 24 February 2015
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	* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.		* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.
	* 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.		* 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.
	* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use ~~extreme~~ caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.		* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.
	* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}		* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}

GameComplete at 07:29, 24 February 2015

2015-02-24T07:29:25Z

← Older revision		Revision as of 07:29, 24 February 2015
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	== Chemical and physical properties ==		== Chemical and physical properties ==
	From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />		From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />
	Sharing a strong structural similarity with [[ALD-52]], the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
	Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from [[David E. Nichols]] believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.

	"I am sure that the 1-[[propionyl]] would also hydrolyze off of an [[indole]], but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the [[5-HT2A receptor]], the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>		''Sharing a strong structural similarity with ALD-52, the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
			''Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from David E. Nichols believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.''

			''"I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>''
	<!--== Effects ==		<!--== Effects ==

GameComplete at 07:26, 24 February 2015

2015-02-24T07:26:19Z

← Older revision		Revision as of 07:26, 24 February 2015
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	\|		\|
	* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.		* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.
	* 1P-LSD is ~~probably~~ a controlled substance analogue under US law if intended for human consumption.		* 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.
	* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.		* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.
	* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}		* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}

GameComplete at 07:24, 24 February 2015

2015-02-24T07:24:15Z

← Older revision		Revision as of 07:24, 24 February 2015
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	* No other known specific physical risks at this time.		* No other known specific physical risks at this time.
	\|		\|
	* 1P-LSD is a ~~substance~~ not mentioned in academic literature~~, with little known about its pharmacological or behavioral risks~~. The LD50 (median lethal dose) ~~is not known.~~		* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.
	* No studies on this substance have been performed, so long term ~~effects and potential~~ risks are ~~UNKNOWN!~~
	* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.		* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.
	* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.		* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.

GameComplete at 07:17, 24 February 2015

2015-02-24T07:17:21Z

← Older revision		Revision as of 07:17, 24 February 2015
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	* No studies on this substance have been performed, so long term effects and potential risks are UNKNOWN!		* No studies on this substance have been performed, so long term effects and potential risks are UNKNOWN!
	* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.		* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.
	* ~~Warning:~~ This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.		* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.
	* ~~Warning:~~ Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}		* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}

	[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]		[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]

GameComplete at 07:12, 24 February 2015

2015-02-24T07:12:19Z

← Older revision		Revision as of 07:12, 24 February 2015
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	* Open and closed eye visuals, euphoria, change in perception of time. Anecdotal report of being indistinguishable from LSD.		* Open and closed eye visuals, euphoria, change in perception of time. Anecdotal report of being indistinguishable from LSD.
	\|		\|
	* Possible side effects: nausea, vasoconstriction ~~(mostly when combined with other vasoconstricting substances like LSD)~~, unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing		* Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
	\|		\|
	* Possible mental side effects: paranoia, fear, and panic. Hallucinogen persisting perception disorder.		* Possible mental side effects: paranoia, fear, and panic. Hallucinogen persisting perception disorder.
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	* 1P-LSD is a substance not mentioned in academic literature, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.		* 1P-LSD is a substance not mentioned in academic literature, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
	* No studies on this substance have been performed, so long term effects and potential risks are UNKNOWN!		* No studies on this substance have been performed, so long term effects and potential risks are UNKNOWN!
	* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.}}		* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.
			* Warning: This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.
			* Warning: Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}

	[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]		[[Image:1P-LSD.png\|right\|thumb\|200px\|1P-LSD]]
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	== References ==		== References ==
	<references />		<references />
	~~{{Page Footer\|Allies and Associated Alkaloids}}~~
	[[Category:~~Alkaloids~~]]		[[Category:Research Chemicals]]

GameComplete at 07:02, 24 February 2015

2015-02-24T07:02:35Z

← Older revision		Revision as of 07:02, 24 February 2015
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	== Brief overview - What is 1P-LSD? ==		== Brief overview - What is 1P-LSD? ==
	* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide]		* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

	== Chemical and physical properties ==		== Chemical and physical properties ==